A total approximate number of 50 individuals of adult Mugil cephalus (L.) were caught at random from the selected locations. All fish used were of uniform size ((14-15.50cm) and weight 85-100gm. levels of cadmium (Cd), Cromium (Cr), manganese (Mn), nickel (Ni) and lead (Pb) increased significantly in loc#1 (polluted location) compared toloc#2 (less polluted). Also concentrations of these metals in location #1 exceeded the USEPA permissible levels. Levels of total protein and albumin were decreased significantly. Levels of AST and ALT were increased significantly compared to loc#2. GSH and GST were depleted in blood of fish of loc #1 indicating the role of GSH as scavenger of reactive oxygen species.

The present investigation was carried out to evaluate the protective effects of Murayya koenigii leaf extract against cyclophosphamide induced genotoxicity in bone marrow cells of mice. The administration of Murraya koenigii leaf extract (MKL) extract at various doses i.e. 100, 200and 400mg /kg. When treated individually did not induce chromosomal aberrations in somatic cells of mice in 24hrs. A single Intraperitoneal administration of 50mg/kg of cyclophosphamide induced significant increase in the percentage of CAS insomatic cells of mice. However after co administration of three doses of MKL extract there was a dose dependent decrease in the % of CAS was observed. When animals were administered with MKL 100, 200 and 400mg/kg/bw orally for seven days prioer to Cyclophasrimide (50mg/kg/bw) was given intraperitoneally as a single dose. For each experimental group control, animals were maintained. 24hrs after the administration of the last dose, the animals were sacrificed and air dried metaphase preparations were made and processed for identification of chromosomal aberrations in somatic cells of mice. An increase in the percentage of Chromosomal aberrations was observed after 50mg/kg of Cyclophosphamide in treatment. But when animals primed with MKL, there was a decrease in the frequency of chromosomal aberrations. Thus the results clearly indicated the protective role of MKL on Cyclophosphamide induced genotoxic damage in somatic cells of mice.

Regenerative medicine is a branch of medicine that will create attempts to change the course of chronic disease and restore fatigued and damaged organs in many instances. It is a tissue engineering and molecular biology branch of translational research that deals with the process of replacing, modifying or regenerating human cells, tissues or organs to restore or create normal function. Regenerative medicine It also involves the prospect of developing and safely implanting tissues and organs in the laboratory when the body cannot repair itself. Regenerative medicine refers to a group of biomedical clinical treatment strategies which may include the use of stem cells. Examples include injection of stem cells or progenitor cells (cell therapy); activation of regeneration by biologically active molecules administered alone or by secretion of infected cells (immune-modulation therapy) and by transplantation of in vitro cultured organs and tissues (tissue engineering). Stem cell therapy is the use of stem cells for treatment or prevents disease or disease. Research is underway to develop various sources for stem cells, and to apply stem cell treatments for neurodegenerative diseases and conditions, diabetes, heart disease, spinal cord injuries, retinal disease, Parkinson's disease, cancer, and other conditions.

Objective: This study aimed to investigate the antibacterial activity of aqueous and alcoholic extracts of Aloe vera (Aloe barbadensis) on the growth of gram-positive bacteria Staphylococcus aureus. Methods: The cultured medium for bacteria was obtained in a dehydrated form and contained beef extract, yeast extract, peptone, sodium chloride, and agar. The antibacterial activity of different concentrations of the aqueous and ethanolic extracts of A. barbadensis was tested against Gram-positive bacteria (S. aureus). The methods used to determine the antibacterial activity of the plant extracts were agar well diffusion assay and gentamicin was used as a positive control and distilled water as a negative control. All the tests were performed in triplets. Results: All concentrations of the aqueous and alcoholic extracts of A. barbadensis exhibited a significantly high inhibitory effect against the linear growth of S. aureus compared to gentamycin. The highest concentration of the aqueous and alcoholic extracts of A. barbadensis at (25, 50 and 100%), gave significantly higher inhibition zones (16, 14 and 10%) respectively compared to the untreated control in day four after inoculation. The aqueous extract was the most effective in suppressing the bacteria growth than its alcoholic extracts and gentamycin. Conclusion: As the concentration of the extracts increased, the radius of the zones of inhibition also increased which implies good antibacterial activity.

A Corona virus is a common large family of virus that causes an infection in human respiratory tract such as nose, sinuses upper throat and lungs. It causes the infection ranging from common cold to severe illness (MERS and SARS). COVID- 19 (Corona Virus Disease-2019) is an acute infectious respiratory disease caused by a newly discovered corona virus (SARS-COV-2) is a highly spreadable disease. The World Health Organization (WHO) has stated the current epidemic to be a global public health emergency. Presently, the research on SARS-CoV-2 is in its initial phases. Based on recent available evidence, this review of COVID-19 analytically summarizes the pathogenesis, clinical features, diagnosis, transmission and prevention of COVID-19. We hope that this review will give the guidance to the public and health care peoples to identify and deal with SARS-CoV-2 disease and also it might be provide a reference for carry out the future studies and research on COVID-19.