Quercetin-flavonoid-polyphenolic has gained attention in prevention of brain cancer. The low permeability of Quercetin (QUR) across the blood-brain-barrier (BBB) leads to its insufficient delivery which in turns result in low therapeutic index. Therefore, developing a novel approaches enhancing the CNS delivery of QUR are required for the treatment of Cancer. The aim of this research work was to develop in Microemulsion (ME) loaded with QUR, for CNS targeting. Quercetin is a poorly water soluble anticancer drug, with oral bioavailability is about 4%. Microemulsion were fabricated by Spontaneous Emulsification technique. Oleic acid was used as oil. Tween 80 was employed as surfactant and Polyethylene glycol 400 was employed as co-surfactant. QUR loaded ME for intranasal delivery are considered as promising vehicle for its targeting to CNS to treat the brain cancer.

Curcumin (CRM) is a polyphenolic compound and it is used for treatment of several inflammatory diseases, Alzheimer‟s, and brain cancer. CRM having major activity to inhibit vascular endothelial growth factor (VEGF) is responsible for angiogenesis. Curcumin (CRM) loaded Nanoemulsion (NE) was fabricated by Vortexing technique and Centre composite rotable design response surface model (CCRD-RSM) was employed; three independent factors such as oil (A), surfactant (B) and co-surfactant (C) concentration were used. Optimised nanoemulsion (NE) (F19) had drug content of CRM (X) was 99.98 ± 0.54 (%) and droplet size (Y) 34.98 ± 0.25 (nm) respectively. This design, the best models such as linear model can be selected due to the analysis of variance (ANOVA) F-value and P value < 0.05 which is considered to be statistically significant. Response surface model was used to determine interaction pattern of independent and dependent variables. All concentrations of independent variables shows significant effect on dependent variables.

Gestational diabetes mellitus (GDM) is commonly defined as glucose intolerance first recognized during pregnancy. Diagnostic criteria for GDM have changed over the decades. Perinatal and postpartum complications associated with GDM include preterm delivery, shoulder dystocia, stillbirths, clinical neonatal hypoglycemia, hyperbilirubinemia, cesarean deliveries, obesity and cardiovascular disease in the mothers. Management strategies increasingly emphasize optimal management of fetal growth and weight. Monitoring of glucose and fetal weight through ultrasound combined with maternal weight management, medical nutritional therapy, physical activity, and pharmacotherapy can decrease co morbidities associated with GDM. Consensus is lacking on ideal glucose targets, degree of caloric restriction and content, algorithms for pharmacotherapy, and in particular, the use of oral medications and insulin analogs in lieu of human insulin. Postpartum glucose screening and initiation of healthy lifestyle behaviors, including exercise, adequate fruit and vegetable intake, breastfeeding, and contraception, are encouraged to decrease rates of future glucose intolerance in mothers and offspring.

Isolation and identification of microorganisms from locally prepared Zobo drink in Konduga town were carried out using standard bacteriological analysis. The results obtained showed that, all the samples were contaminated with different microorganisms which include; Klebsiella Species, E. coli, Proteus Species, Pseudomonas Species, Salmonella Species and Staphylococcus aureus. Sample from Ajari (H) and Fulatari (I) contained six potentially pathogenic bacteria. Ajari (H) had the highest total heterotrophic count of 5.0x106 while G.G.C low cost (F) had the lowest cfu/ml of 3.5x106. E. coli was the most prevalent isolates from all the samples with the overall frequency of 22 (25.0 %). Therefore, there is a need to educate the producer of such products on the importance hygiene at various stages of processing and at the point of sale. This will greatly enhance and improve the quality of the products and it will reduce the incidence of food born poisoning caused by consumption of contaminated food products.

The Plant material C. acuminata is prominent for its fruit (kolanut) which is widely consumed amongst many cultures in West Africa. The preliminary phytochemical screening of the leaf extract of cola acuminate revealed the presence of cardiac glycoside, flavonoid, tannins, carbohydrate, anthraquinone glycoside, steroid and alkaloid. Column chromatography of the aqueous ethanol extract was conducted using prepared column set-up, the aqueous ethanol extract was ran with n-hexane, chloroform and methanol at different ratios. The TLC profile of the leaves extract using the above stated solvent system showed characteristic distinct spots as obtained from TLC plate 1 and 2 using different spraying agent with characteristic Rf values. The above mentioned extract were evaluated for their antioxidant/free radical scavenging activities at concentration 10µg/ml, 20µg/ml, 30µg/ml, 40µg/ml and 50µg/ml using DPPH assay method and vitamin C as a standard. The activity was more prominent in the non-polar component (n-hexane extract) than the polar component (ethanol extract). The DPPH/TLC assay conducted on the column fractions confirmed the presence of antioxidant principles on the leaf extract of C. acuminata.