Triticum aestivum, Spinacia oleracea, Chromolaena odorataplants have been analysed for the determination of food content viz, protein, glucose, ascorbic acid content and chlorophyll a, b and carotenoid. The concerned plants responded very well towards all the contents. Chlorophyll content was found highest in acetone and methanol extract of Triticum aestivum, Spinacia ocelera followed byEupatorium odoratum, but the diethyl ether extract of eupatorium posses more chlorophyll (a) content than that of Triticum aestivum, Spinacia ocelera. The chlorophyll (b) content was found highest in the acetone extract of Triticum aestivum followed by diethyl ether extract of Eupatorium odoratum. The carotenoid content was found highest in all the acetone extracts of the concerned three plants followed by methanol extract, and fewer contents were found present in diethyl ether extracts of all plants. The glucose content was found highest in the acetone extracts followed by methanol extracts and lesser amount of carotenoids was found present in the diethyl ether extracts. Among the Triticum aestivum, Spinacia ocelera, Eupatorium odoratum, the ascorbic acid was found highest in acetone extracts followed by methanol extracts and fewer in the diethyl ether extracts. The protein content was found highest in the diethyl ether extract Spinacia ocelera followed by acetone extract and little amount was found in methanol extract of the concerned plants.
M. Amin Mir*, Narender Kumar, Pooja Dogra, Bilal Ahmad.
Nature has been a source of medicinal agents for thousands of years and an impressive number of modern drugs have been isolated from natural resources. Traditional medicine is an important source of potentially useful new compounds for the development of chemotherapeutic agents. The essential values and uses of some plants have been worked out and published, but many of them remain unexplored to date. Therefore, there is a necessity to explore their uses and to conduct pharmacognostic and pharmacological studies to discover their medicinal properties. Tridax procumbens (L.) is a spreading annual herb found throughout India but unfortunately it is one of the neglected plants. Hence, the present review aims to open new avenues for the improvement of medicinal use of Tridax procumbens (Compositae) for various ailments and to bring the anti-diabetic medicinal plant to the scientists' notice, and raise awareness and add value to the resource. This review attempts to highlight the available literature on Tridax procumbens (L.) A study had found anti-cancer properties of Tridax procumbens against human prostate epithelial cancer cell line PC 3. Also pharmacological activities like hepatoprotective activity, antidiabetic activity, antiinflammatory, wound healing, antidiabetic activity, hypotensive effect, immunomodulating property, bronchial catarrh, dysentery, diarrhoea and to prevent falling of hair, promotes the growth of hair, and antimicrobial activity against both Gram-positive and Gram-negative bacteria.
Various types of lipid based vesicular systems have been developed in controlled and targeted drug delivery system. Pharmacosomes is a novel vesicular drug delivery system, bearing unique advantages over liposome and noisome have come up as potential alternative to conventional vesicles. Pharmacosomes are the amphiphilic phospholipids complexes of drugs bearing active hydrogen that bind to phospholipids. They provide an efficient method for delivery of drug directly to the site of infection, leading to reduction of drug toxicity with no adverse effects and also reduces the cost of therapy by imparting better biopharmaceutical properties to the drug, resulting in improved bioavailability, especially in case of poorly soluble drugs. This system shows low entrapment efficiency and drug leakage during storage for hydrophilic drugs. They help in controlled release of drug at the site of action as well as in reduction in cost of therapy, drug leakage and toxicity, increased bioavailability of poorly soluble drugs, and restorative effects. Pharmacosomes have advantages over liposomal, transferosomal, and niosomal drug delivery systems. They are mainly prepared by hand-shaking and ether injection method. The Pharmacosomes were evaluated for different parameters such as size, surface morphology and In vitro release rate. It is advancing as a method used for delivery of various drugs like non-steroidal anti-inflammatory drugs, cardiovascular drugs, antineoplastic drugs and proteins. This article reviews the potential of pharmacosomes as a controlled and targeted drug delivery system and highlights the methods of preparation and characterization.
The chronopharmacotherapy drug delivery system is widely used for treatment of diseases occurs due to circadian changes in the body. This system is aims to release drugs at a programmed pattern i.e.at appropriate time and/or at appropriate site of action. In this investigation, a novel oral pulsatile drug delivery system based on a core-in-cup dry coated tablet, where a core tablet surrounded on the bottom and circumference wall with inactive material. The system consists of three parts, a core tablet, containing the active ingredient, an impermeable outer shell and top cover layer of hydrophilic polymer. The core containing Eprosartan Mesylate as a bioactive compound was prepared by direct compression method and evaluated for thickness, hardness, weight variation and friability. The impermeable coating cup consisted of hydrophobic polymer of cellulose acetate propionate, and the top cover layer of hydrophilic swellable materials (Sodium Alginate, HPMC K4M, Sodium carboxy methylcellulose,) were used in different concentration. The tablets prepared were evaluated for Micromeritic properties, hardness, thickness, weight variation, friability, drug content uniformity and in-vitro drug release study. The drug-excipients study was carried out by using FT-IR. From the obtained results, it was found that the order of sustaining capacity of pulsatile device is, HPMC K4M > Sodium CMC > Sodium alginate.
Hypertension is one of the major chronic diseases resulting in high mortality and morbidity in today’s world. High blood pressure is called as silent killer because it damages our health without making one feel sick. Socio-economic, behavioral and nutritional and public health issues have also led to increase in cardiovascular disease throughout the world. The basic aim of this study is to assess the awareness and knowledge of patients about hypertension. Assessment of patients’ knowledge about the disease and its treatment are the key components for planning an effective educational intervention. Based on expert reviews and content validity evaluation, a 23- item questionnaire was designed and piloted. Items were added, modified and deleted based on the discussions during the various changes of development of questionnaire.A total of each 50 questionnaires were collected from the patients. An attempt was made to categorize the overall study population based on their gender, family history. The sample consisted of 32 male and 18 female patients. The analysis revealed that most of the patients were educated, 70% of patients were skilled employee. 40% of patients were suffering from hypertension for more than 2 years. 64% patients were taken other medication for their other illness. Thereareseverallimitationstotheinterpretationsof thisstudy.Currently, thereisno standardizedinstrument availabletoassesshypertension knowledge,attitudesandlife-style practices. The finding of the study may be useful in developing more effective education strategies for hypertensive patients in near future.
A. Vikneswari*, S. Parthiban, Faiz Amil, T. Tamizh Mani.