Novel Drug Delivery System oriented towards increasing safety and efficacy of existing drug molecule through novel concepts like oral drug delivery system. In that the basic approach used in the development of the oral dispersible tablets by using different super disintegrants. Another approach used in developing oral dispersible tablets is maximizing pore structure of the tablets. Freeze-drying and vacuum-drying techniques have been tried by researchers to maximize the pore structure of tablet matrix. Tablets containing Atenolol with super disintegrants like Starch citrate, Sodium starch glycolate and cross carmellose sodium were prepared by direct compression technique. The tablets were evaluated for percentage friability, wetting time, disintegration time and in vitro studies etc.
After the success of human genome project, proteome is a new emerging field of biochemistry as it provides the knowledge of enzymes (proteins) interactions with different body organs and medicines administrated into human body. Therefore, the study of proteomics is very important for the development of new and effective drugs to control many lethal diseases. In proteomics study, analyses of proteome is essential and significant from the pathological point of views, i.e., in several serious diseases such as cancer, Alzheimer’s disease and aging, heart diseases and also for plant biology. The separation and identification of proteomics is a challenging job due to their complex structures and closely related physico-chemical behaviors. However, the recent advances in liquid chromatography make this job easy. Various kinds of liquid chromatography, along with different detectors and optimization strategies, have been discussed in this article. Besides, attempts have been made to include chirality concept in proteomics for understanding mechanism and medication of various disease controlled by different body proteins.
The formulation of poorly soluble compounds for oral delivery at present is one of the most frequent and greatest challenges to formulation scientists in the pharmaceutical industry. Omeprazole magnesium comes under class II of BCS classification which means low solubility and high permeability. Low solubility of omeprazole magnesium leads to bioavailability problems. Increasing the solubility of omeprazole magnesium can increase the bioavailability of the drug. Solid dispersion and slugging method is employed to increase solubility of drug. The solid dispersion of omeprazole magnesium by solvent evaporation, and fusion method were prepared using PVPK-30, urea and PEG 6000, in ratios 1:1, 1:2and 1:3 .Slugging of omeprazole magnesium using excipient like lactose and sodium chloride in different ratios 1:1, 1:2 and 1:3 also enhances solubility of the drug. Solid dispersion of Omeprazole magnesium with solvent evaporation technique (PVP-K: ethanol) showed higher drug solubility in comparison to other technique like slugging method and fusion method.Slugging method is next better alternative to improve solubility of omeprazole magnesium.
S. Shahid Mohammed*, K. Viswaganga Pranush, G. Venkatarajagopal Reddy.
The present work deals with Pharmacognostic evaluation and phytochemical screening for hydroalcoholic extract of leaves of medicinal plant Anthocephalus cadamba (Roxb.)Miq. The scientific parameter is necessary to identify the exact plant material and to find its quality and purity. The present study deals with various, physical, chemical evaluation and preliminary phytochemical screening of the alkaloidal content of stem bark of the title plant has been determined. These studies indicated the possible information for correct identification and standardization of this plant material for its Antifungal action.
Aristolochia is an important genus in the family of Aristolochiaceae. The genus Aristolochia consists of about 400 species of herbaceous perennials, under shrubs or shrubs bearing essential oils and is widespread across Tropical Asia, Africa and South America. Aristolochia species has been used extensively in the traditional Chinese medicine. Its diverse biological functions include hypertension relief, leukocyte enhancement, rheumatism relief, edema therapy, as well as analgesic and diuretic effects. Various Aristolochia species have been used in herbal medicines since antiquity in obstetrics and in treatment of snakebite, festering wounds, and tumors, and they remain in use particularly in Chinese herbal medicine.
Payal Chawla*, Amit Chawla, Gagan Shah, U.S. Baghel, R.K. Dhawan.